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Background: Single-nucleotide polymorphisms (SNPs) in the TNFAIP3, IFIH1, and IRF5 genes have been associated with several auto-inflammation diseases.This study was aimed to investigate whether TNFAIP3, IFIH1, and IRF5 genes polymorphisms confer susceptibility for the idiopathic inflammatory myopathies (IIMs) in Chinese Han population.