Amyloid beta(Aβ),the characteristic molecular of AD pathological changes,would be induced nerve cell fleetly apoptosis with direct or indirect way,recently research discovered that decreased Aβ load is simpleness and availability than that to avoid create . Innate immunity system are not only could decreased Aβ load in brain,but could be induced many kinds factors which will be aggravation of AD. TLRs signal passageway is the main passageway of Innate immunity system,Myeloid differentiation factor 88(MyD88) is the adaptor molecule for most of these innate immune receptors.