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While many regard computer-aided drug design (CADD) as synonymous with structure-based design,its use in modern drug discovery research is much broader.In this talk,examples of real-world successes of CADD will be described to highlight its use across a spectrum of drug discovery research activities:lead discovery -building compound libraries -virtual screening -hit-to-lead lead optimization -designing potent ligands via structure-based design (iterative use of Xray co-crystal complexes) -modelling pharmacokinetic properties:absorption/distribution/metabolism/excretion (ADME).