As a privileged N-heterocycle,imidazo[1,2-α]pyridines have exhibited various biological activities.1 With properly installation of amidomethyl,hydroxylmethyl,or other groups at C3 position followed by subsequent elaboration,various commercialized drugs.1 In our work,we we have successfully disclosed a facile and efficient methodology for oxidative C3 sulfonamidomethylation of imidazopyridine using methanol as the main methylene source.A broad range of functionalities were well tolerated to afford the corresponding sulfonamidomethylated products in high yields.Considering the known imidazopyridine-containing commercialized drugs,the obtained methylene-bridged imidazopyridine derivatives may find application in medicinal chemistry.