【摘 要】
：
Amyloid precursor protein (APP) plays important role in the generation of Alzheimers disease (AD).In our previous study,miR-193b was found to be downregulated in hippocampus from 9 mounth old APP/PS1
【机 构】
：
Department of Clinical Laboratory,Xuanwu Hospital,Capital Medical University
【出 处】
：
中华医学会第八次全国中青年检验医学学术会议
论文部分内容阅读
Amyloid precursor protein (APP) plays important role in the generation of Alzheimers disease (AD).In our previous study,miR-193b was found to be downregulated in hippocampus from 9 mounth old APP/PS1 double-transgenic mice using microRNA (miR) array.In this study,bioinformatic analyses showed that miR-193b was a miR that predicted to potentially target 3′-UTRs of APP.The function of miR-193b on APP was studied.Levels of miR-193b,exosomal miR-193b,Aβ,tau,p-tau,HCY,and APOE in samples from APP/PS1 double-transgenic mice,mild cognitive impairment (MCI) and dementia of Alzheimer type (DAT) patients were measured.
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