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  5. Involvement of the prostaglandin E receptor, EP2, In paeoniflorin-induced human hepatoma cells apopt

Involvement of the prostaglandin E receptor, EP2, In paeoniflorin-induced human hepatoma cells apopt

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：zjj008
【摘 要】
：
Aim: Prostaglandin E2 (PGE2) has been shown to play an important role in tumor development and progression.PGE2 mediates its biological activity by binding any one of four prostanoid receptors (EP1 th
【作 者】
：
Shan-shan HU Di WANG Juan JIN Jing-jing WU Jing-yu CHEN Hua-xun WU Qing-tong WANG Wu-yi SUN Wei WEI 
【机 构】
：
Institute of Clinical Pharmacology,Anhui Medical University,key Laboratory of Anti-inflammatory and
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
paeoniflorin butaprost EP2 hepatocellular carcinoma apoptosis caspase-3 
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Aim: Prostaglandin E2 (PGE2) has been shown to play an important role in tumor development and progression.PGE2 mediates its biological activity by binding any one of four prostanoid receptors (EP1 through EP4).The present study was designed to investigate the role of the EP2 receptor during proliferation and apoptosis of human HepG2 and SMMC-7721 hepatoma cell lines and the effect of paeoniflorin,a monoterpene glucoside.
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