Evaluation on hepatoprotection of isoliquiritigenin via oxidation/chemical stress defense pathway Nr

来源 :2015年第一届药代动力学朝阳论坛 | 被引量 : 0次 | 上传用户：lyhl1949

【摘要】

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【作者】

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YAN Miao DENG Yang LI Huan-de

【机构】

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Institute of Clinical Pharmacy, Central South University;Department of Pharmacy, the Second Xiangya

【出处】

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2015年第一届药代动力学朝阳论坛

【发表日期】

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2015年9期

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　　Metabolic profile of bile acids was used to evaluate hepatoprotec tion in Nrf2/ARE Oxidation/chemical stress defense pathway caused by Isoliquiritigenin (ISL) based on analysis of 16 bile acids in mice hepatic tissue.High performance liquid chromatography coupled with quadrupole mass spectrometry (HPLC-MS/MS) was applied to determine the contents of various kinds of endogenous bile acids including free bile acids, taurine conjugates and glycine conjugates.Luciferase reporter gene assay, screening licorice-derived compounds targeting Nrf2/ARE signal pathway, showed that ISL was capable of activating Nrf2-driven gene expression.

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Evaluation on hepatoprotection of isoliquiritigenin via oxidation/chemical stress defense pathway Nr

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