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Background Hypertension affects > 18.8% of adults in China.Indeed,hypertension is the most prevalent risk factor for cardiovascular morbidity and mortality worldwide.Genetic variation is thought to contribute to the etiology of hypertension.NEDD4L is a candidate gene for hypertension,both functionally and genetically.The purpose of the current study was to investigate the relationship between the variation in NEDD4L and essential hypertension in Kazakh,which is a relatively isolated population with a pure genetic background and is an ideal population to study genetic mechanisms of hypertension.