Toll-like receptor 8(TLR8)is one of the evolutionally conserved pattern recognition receptors(PRRs).TLR8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polariz
MEK1 inhibitors are promising molecules in a number of therapies related to cancer,virus infection,inflammation and numerous other diseases[1].Utilizing scaffold hopping strategy,three novel scaffolds
The acquired immunodeficiency syndrome(AIDS)is caused by the human immunodeficiency virus(HIV),which having seriously threatened peoples health and survival.
There is a recent strategy of designing multi-functional ligands by which multiple targets can be inhibited by a single compound.Also,multipleligand approach can benefit anti-HIV discovery since the p
Poly(ADP-ribose)polymerase(PARP)is a large family of multifunctional enzyme in eukaryotic cells.PARP-1 occupies the largest proportion and accounts for more than 90%functions.[1] Upon activation in re
Host defense against foreign genetic elements is one of the most fundamental functions of a living organism.The presence of self or foreign DNA in the cytoplasm is sensed by eukaryotic cells as a dang