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目的:观察中西医结合疗法对高血压晨峰现象控制的效果并进行评价。方法:2006年9月—2007年8月选取本院住院期间具晨峰现象的高血压患者85例,随机分为治疗组和对照组,对照组患者每天晨起口服氨氯地平(络活喜)片剂5mg,苯那普利(洛汀新)片剂10mg;治疗组在此基础上加用杞菊地黄口服液每次10mL,1日3次,共治疗2月。结果:治疗2月后,治疗组、对照组醒后2h血压(SBP)较治疗前下降,有统计学差异(P<0.05),治疗组的晨峰血压SBP较治疗前下降,差异有统计学意义(P<0.05);对照组的有效率为80.9%,治疗组的有效率为95.3%,治疗组的有效率比对照组高,差异有统计学意义(P<0.05)。结论:中西医结合疗法在控制高血压晨峰方面疗效优于单纯西医疗法,中医抗高血压晨峰的具体机制尚待进一步研究。
Objective: To observe the effect of integrated traditional Chinese and western medicine on hypertensive morning peak phenomenon control and evaluation. Methods: From September 2006 to August 2007, 85 hypertensive patients with morning peaks in our hospital were randomly divided into treatment group and control group. Patients in the control group were treated with amlodipine daily morning ) Tablets 5mg, benazepril (Lotensin) tablets 10mg; treatment group on the basis of plus Qijudihuang oral solution 10mL, 1 3 times a day for a total of 2 months. Results: After 2 months of treatment, the blood pressure (SBP) at 2h after treatment in treatment group and control group decreased significantly compared with that before treatment (P <0.05). The SBP of morning peak pressure in treatment group decreased significantly compared with that before treatment (P <0.05). The effective rate of the control group was 80.9% and the effective rate of the treatment group was 95.3%. The effective rate of the treatment group was higher than that of the control group (P <0.05). Conclusion: The combination of traditional Chinese medicine and western medicine treatment is superior to western medicine in controlling morning peak of hypertension, and the specific mechanism of Chinese medicine antihypertensive morning peak remains to be further studied.