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Aim: Gram-negative bacterial sepsis remains a common life-threatening event.Lipopolysaccharide (LPS), a component of the outer membrane of gram-negative bacteria has been implicated in the pathological process of sepsis.Cyclooxygenase (COX)-2 catalyzes the conversion of arachidonic acid to prostaglandins, which play important roles in various homeostatic and inflammatory processes throughout the body.