THE PROTECTIVE EFFECTS OF DANQI ON MYOCARDIAL ISCHEMIA REPERFUSION INJURY IN RABBITS

来源 :第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会 | 被引量 : 0次 | 上传用户：xingchen1023

【摘要】

：

【作者】

：

周玉娟杨琳李少春张智

【机构】

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河北大学基础医学院药理学教研室,河北保定 071000 河北大学研究生学院

【出处】

：

第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会

【发表日期】

：

2013年4期

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目的:如何有效防治心肌缺血再灌注损伤(MIRI)一直是研究的热点问题.临床研究证明丹七具有改善心肌缺血、提高耐缺氧能力、镇痛、降低血脂和血液粘度等作用.实验观察丹七对家兔心肌缺血再灌注损伤的保护作用.方法:实验分组与给药健康清洁级新西兰大耳白18只,体重2.2～2.5kg,随机分为三组:假手术组、模型组、丹七干预组,分别给予蒸馏水、蒸馏水、丹七片400mg·kg-1·d-1灌胃,连续应用1周.末次给药后1h,采用结扎家兔左冠状动脉前降支的方法制备缺血再灌注损伤模型,观察丹七对左室功能、血清中肌酸激酶(CK)、乳酸脱氢酶(LDH)、一氧化氮(NO)、一氧化氮合酶(NOS)的影响.

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THE PROTECTIVE EFFECTS OF DANQI ON MYOCARDIAL ISCHEMIA REPERFUSION INJURY IN RABBITS

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