THE PROTECTIVE EFFECTS OF DANQI ON MYOCARDIAL ISCHEMIA REPERFUSION INJURY IN RABBITS

来源 :第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会 | 被引量 : 0次 | 上传用户:xingchen1023
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的:如何有效防治心肌缺血再灌注损伤(MIRI)一直是研究的热点问题.临床研究证明丹七具有改善心肌缺血、提高耐缺氧能力、镇痛、降低血脂和血液粘度等作用.实验观察丹七对家兔心肌缺血再灌注损伤的保护作用.方法:实验分组与给药健康清洁级新西兰大耳白18只,体重2.2~2.5kg,随机分为三组:假手术组、模型组、丹七干预组,分别给予蒸馏水、蒸馏水、丹七片400mg·kg-1·d-1灌胃,连续应用1周.末次给药后1h,采用结扎家兔左冠状动脉前降支的方法制备缺血再灌注损伤模型,观察丹七对左室功能、血清中肌酸激酶(CK)、乳酸脱氢酶(LDH)、一氧化氮(NO)、一氧化氮合酶(NOS)的影响.
其他文献
Hypoestes purpurea R.Brown (H.P.)(六角英), Procumbent Tridax (P.T.)(長柄菊), Emilia sonchifolia (E.S.)(一點紅) and Tithonia Diversifolia (T.D.)(五爪金英) are usually used in healthy tea.The healthy tea is associat
会议
Spinal cord injury (SCI)-induced secondary oxidative stress associates with a clinical complication and high mortality.Treatments to improve the neurological outcome of secondary injury are considered
会议
ClC-3 chloride channel, plays an important role in the regulation of cell volume, proliferation and apoptosis.Preadipocytes of type 2 diabetes show a tendency to enhanced apoptosis.We hypothesized tha
会议
Cardiac side population cells (CSPs) are promising cell resource for the regeneration in diseased heart as intrinsic cardiac stem cells.However the relative low ratio of CSPs in the heart limited the
To evaluate the role of the DNA methylation of the CpG island within the PON1 promoter on the clinical efficacy of the dual-antiplatelet therapy of aspirin and clopidogrel in patients with CAD after p
会议
Aims: Pellinol is an evolutionally conserved immune regulator and participates in the regulation of activation of Toll-like receptor/intefleukin-1 receptor (TLR/IL-1R)-mediated signaling.TLR/IL-1R sig
Myocardial fibrosis plays a critical role in the process of diabetic cardiac remolding.MicroRNAs are endogenous, small non-coding RNAs that negatively regulate gene expression in diverse biological an
会议
OBJECTIVE: To investigate whether Clq/TNF-related protein (CTRP) 6 is involved in vascular smooth muscle cell (VSMC) migration and neointima formation in response to vascular injury.METHODS:Male Sprag
会议
目的:观察成体大鼠局灶性脑缺血后,激活的小胶质细胞是否如同胚胎时期和生后早期大鼠脑内的阿米巴样小胶质细胞一样,再次表达血管紧张素Ⅱ(AngⅡ)及其受体(AT1和AT2受体),且表达变化规律如何;研究AngⅡ及其受体与脑缺血及激活的小胶质细胞三者之间的关系,探讨脑缺血的发病机理.方法:采用微创开颅法建立大鼠大脑中动脉闭塞(MCAO)模型,将81只成年雄性SD大鼠分为正常对照组(n=9),假手术组(n
会议
P-glycoprotein(P-gp)is one of the transmembrane protein of ATP-binding cassette (ABC)which be encoded by Mdr1 gene.Increasing research demonstrated the expression of P-gp increased in epilepsy and cer
会议