【摘 要】
：
Cardiac side population cells (CSPs) are promising cell resource for the regeneration in diseased heart as intrinsic cardiac stem cells.However the relative low ratio of CSPs in the heart limited the
【机 构】
：
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Scien
【出 处】
：
第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会
论文部分内容阅读
Cardiac side population cells (CSPs) are promising cell resource for the regeneration in diseased heart as intrinsic cardiac stem cells.However the relative low ratio of CSPs in the heart limited the ability of CSPs to repair heart and improve cardiac function effectively under pathophysiological condition.Which factors limiting the proliferation of CSPs in diseased heart are unclear.Here, we show that urotensin Ⅱ (UⅡ) regulates the proliferation of CSPs by c-Jun N-terminal kinase (JNK) and low density lipoprotein receptor-related protein 6 (LRP6) signaling during pressure overload.Pressure overload grealty upregulated UⅡ level in plasma, UⅡ receptor (UT) antagonist, urantide, promoted CSPs proliferation and improved cardiac dysfunction during chronic pressure overload.In cultured CSPs subjected to mechanical stretch (MS), UⅡ significantly inhibited the proliferation by UT.Nanofluidic proteomic immunoassay (NIA) showed it is the JNK activation, but not the extracellular signal-regulated kinas (ERK) activation, that involved in the UⅡ-inhibited-proliferation of CSPs during pressure overload.
其他文献
目的:我们前期研究表明胰高血糖素样肽-1受体(GLP-1R)在高血压中表达下调,而高选择性二肽基肽酶Ⅳ抑制剂磷酸西他列汀(sitagliptin)能够恢复其表达,本研究目的是阐明相关的机制.方法:采用sitagliptin(10 mg.kg-1.d-1)给予自发性高血压大鼠SHR和正常血压对照组大鼠WKY灌胃2周,应用微血管张力测定仪检测血管舒张功能,通过Western blot检测蛋白的表达情况
Aim: In this study, we investigated the question of whether or not treadmill exercise improves motor and cognition functions in an ischemic rat model, and whether or not the result is associated with
Ischemic brain injury is the leading cause of cerebrovascular disease, which is one of the three diseases of highest incidence.Complex pathology could be induced by ischemic brain injury, therefore le
Background: Vascular remodeling is a predominantly feature in hypertension, which relates to the process of vascular smooth muscle cell (VSMC) proliferation and migration.Previous studies have shown t
TG-interacting factor (TGIF) is a transcriptional corepressor of TGF-β signaling that plays a protective role in neuronal damage, such as traumatic brain injury (TBI).TBI is a highly complicated disor
目的 壬基酚(nonylphenol,NP)是环境内分泌干扰物的一种,因具有强大脂溶性而被广泛应用于工业、纺织业及生活用品中,目前对环境的污染甚为严重。众多研究证实NP长期积蓄于生物体内能对生殖系统、内分泌系统及心血管系统等产生不可忽视的毒性作用,而对其急性毒性作用的研究尚不明确。方法 本研究首先将10-7 M NP和10-5 M NP直接灌流离体心脏,观察10-7 M NP和10-5 M NP对
OBJECTIVE: To investigate the activations cyclooxygenase-2 (COX-2)/5-1ipoxygenase (5-LO) pathways of arachidonic acid (AA) metabolism and the protective effects of 13-methyltetradecanoic acid (13-MTD)
Hypoestes purpurea R.Brown (H.P.)(六角英), Procumbent Tridax (P.T.)(長柄菊), Emilia sonchifolia (E.S.)(一點紅) and Tithonia Diversifolia (T.D.)(五爪金英) are usually used in healthy tea.The healthy tea is associat
Spinal cord injury (SCI)-induced secondary oxidative stress associates with a clinical complication and high mortality.Treatments to improve the neurological outcome of secondary injury are considered
ClC-3 chloride channel, plays an important role in the regulation of cell volume, proliferation and apoptosis.Preadipocytes of type 2 diabetes show a tendency to enhanced apoptosis.We hypothesized tha