SILENCING OF PELLINO1 IMPROVES POSTINFARCT CARDIAC DYSFUNCTION AND ATTENUATES LEFT VENTRICULAR REMOD

来源 :第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会 | 被引量 : 0次 | 上传用户：freeangel01

【摘要】

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【作者】

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胡媛萍吴维朱维娜阙玲琍李跃华

【机构】

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中国江苏省南京市汉中路140号,南京医科大学,病理生理学系,江苏省心血管病分子干预重点实验室,210029

【出处】

：

第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会

【发表日期】

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2013年4期

【关键词】

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Myocardial infarction Pellinol TLR/IL-1R Inflammation Left ventricular remodelin

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Aims: Pellinol is an evolutionally conserved immune regulator and participates in the regulation of activation of Toll-like receptor/intefleukin-1 receptor (TLR/IL-1R)-mediated signaling.TLR/IL-1R signaling has been reported to play a role in the left ventricular remodeling after myocardial infarction (MI).However, how Pellinol contributes left ventricular remodeling after MI remains unsolved.This study examined the effect of Pellinol silencing on cardiac function and the left ventricular remodeling after MI.

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SILENCING OF PELLINO1 IMPROVES POSTINFARCT CARDIAC DYSFUNCTION AND ATTENUATES LEFT VENTRICULAR REMOD

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