SILENCING OF PELLINO1 IMPROVES POSTINFARCT CARDIAC DYSFUNCTION AND ATTENUATES LEFT VENTRICULAR REMOD

来源 :第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会 | 被引量 : 0次 | 上传用户:freeangel01
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Aims: Pellinol is an evolutionally conserved immune regulator and participates in the regulation of activation of Toll-like receptor/intefleukin-1 receptor (TLR/IL-1R)-mediated signaling.TLR/IL-1R signaling has been reported to play a role in the left ventricular remodeling after myocardial infarction (MI).However, how Pellinol contributes left ventricular remodeling after MI remains unsolved.This study examined the effect of Pellinol silencing on cardiac function and the left ventricular remodeling after MI.
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