【摘 要】
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Studies of genetic variation in human populations began inauspiciously.The first such study — of ABO blood group frequencies — was carried out by two Polish immunologists, Ludwik and Hanka Hirszfeld,
【机 构】
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Department of Zoology, Shah Abdul Latif University,Khairpur mirs, Sindh,Pakistan
【出 处】
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第二届中国肉牛选育改良与产业发展国际研讨会暨中国畜牧兽医学会养牛分会八届二次学术研讨会
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Studies of genetic variation in human populations began inauspiciously.The first such study — of ABO blood group frequencies — was carried out by two Polish immunologists, Ludwik and Hanka Hirszfeld, at the end of the First World War.This work was notable for its broad coverage of the worlds populations, large sample sizes and scrupulous attention to anthropological details.Yet the Hirszfelds still ran into difficulties in publishing in The Lancet, the premier medical journal of the time.The editor could not see the relevance of their work, and so this seminal study of human genetic variation first appeared in an obscure anthropological journal.The relevance became abundantly clear when Felix Bernstein subsequently used the Hirszfelds data to demonstrate that the ABO blood-group frequencies were better explained by a single gene with three variants (alleles), and not — as prevailing wisdom then held — two genes each with two alleles.Happily, times have changed; diversity is now all the rage, and editors have become more appreciative of the importance of human genetic variation.
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