【摘 要】
：
Treatment of cancer has been dominated by the triad surgery, radiotherapy, chemotherapy, three methods that become palliative when the tumors metastasize.Cancer cells are viewed as having acquired pro
【机 构】
：
Oncology Department Institute of Cancer and Immunogenetics Paul-Brousse Hospital France
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Treatment of cancer has been dominated by the triad surgery, radiotherapy, chemotherapy, three methods that become palliative when the tumors metastasize.Cancer cells are viewed as having acquired properties that define their behaviour in response to a regulating microenvironment: unlimited replication, angiogenesis, resistance to apoptosis, growth autonomy, insensitivity to growth inhibitors, and tissue invasion and metastasis.These intrisic properties of tumor cells steer great research efforts for obtaining control over tumor development.
其他文献
Despite recent improvement of treatment modality, ovarian carcinoma is the leading cause of death in all gynecologic malignancy in the most developed countries, in several histological subtypes of ova
The Hox family of homeodomain transcription factors are essential for the regulation of hematopoiesis and deregulated expression of some Hox gene is associated with the development of myeloproliferati
Tumor suppressor genes RASSF1A and BLU are two tandem head-to-tail genes located at 3p21.3.Therefore, we hypothesized that there may be a regional effect on their gene expression and promoter methylat
Increasing evidence shows that there is an interaction between mitogen-activated protein kinase (MAPK) and Wnt signaling and that their interaction plays important roles in a variety of cellular proce
Approximately 70% of breast cancers are estrogen receptor alpha (ERa)-positive.Drugs that target the estrogen receptor have been a mainstay of breast cancer treatment for nearly 50 years, yet many of
Estrogen receptor (ER) dimerization is prerequisite for its activation of target gene transcription.Because the two forms of ER, ER alpha and ER beta, exhibit opposing functions in cell proliferation,
B-cell receptor (BCR) signaling plays an important role in the pathogenesis of chronic lymphocytic leukemia (CLL).We tested whether blocking BCR signaling with dasatinib, an inhibitor of SRC kinase, w
Estrogens, especially 17β-estradiol or E2, a biologically potent estrogen, play very important roles in the proliferation and development of hormone dependent breast carcinoma cells and some of these
Maximal and sustained activation of T lymphocytes requires integration of the signaling pathways downstream of the TCR (T Cell Receptor) and of coreceptors such as CD28.Upon T cell activation, TCR sig
In renal cell carcinoma (RCC), HKLA class Ⅰ down regulation has been found in 40% of the tumor lesions examined.Since only scanty information is available regarding the molecular basis of these defect