Prussian blue(PB)and its analogues,have attracted growing interest on account of their interesting properties like electrochromicity and ion-exchange selectivity.Captopril is a well-known medicine applied to the treatment of hypertension and congestive heart failure.In this work,Co2+ ions were initially intercalated into the layers of laponite and then cobalt hexacyanoferrates(CoHCFe)were electrogenerated on the surface of laponite-Co2+ modified ITO via square wave voltammetry(SWV).The ITO/laponite/CoHCFe exhibited an enhanced analytical performance for amperometric detection of captopril with two enlarged linear ranges from 3.0×10-7 to 1.27×10-4 M and 1.63×10-4 to 3.76×10-4 M and a low detection limit(0.29 μM).The modified electrode was used for electrocatalytic determination of captopril in some real samples.