【摘 要】
:
Background:Epidemiological studies suggest that hyperglycemia abrogates gender based cardiovascular protection possibly associated with estrogens.Objectives:The objectives of our study were to investi
【机 构】
:
School of Pharmacy & Health Sciences University of the Pacific USA
【出 处】
:
中国上海第七届国际新药发明科技年会
论文部分内容阅读
Background:Epidemiological studies suggest that hyperglycemia abrogates gender based cardiovascular protection possibly associated with estrogens.Objectives:The objectives of our study were to investigate 1) if there is a gender based difference in the relaxation response of rat and rabbit aorta after acute exposure to high glucose (HG),and 2) the potential role of protein kinase C isoforms (-α,-β,-δ) and superoxide in the HG-induced vascular dysfunction.Methods:Endothelium-dependent vasodilator (EDV) responses to acetylcholine (ACh,10-8 to 10-5 M) were obtained before and after 3 h treatment with Krebs solution containing high glucose (46 mM) in aortic rings pre-contracted with phenylephrine (2 μ M) taken from female and male rats (Sprague-Dawley) and rabbits (New Zealand White).Similar experiments were generated in the presence of 9 nM Ro-32-0432,a selective PKC-α inhibitor,1 μ M LY379196,a selective PKC-β inhibitor,6μ M Rottlerin,a selective PKC-δ inhibitor,and 25 μ M MnTMPyP,a superoxide scavenger.
其他文献
The formation of the vascular system is an early step in organogenesis that involves the participation of various signalling pathways.Integration of the extracellular signals decoded by their cognate
Breast cancer is a highly heterogeneous disease that includes HER2/NEU+,basal-like and ER+ tumors.The most aggressive subtypes,basal-like and HER2/NEU+,are treated with chemotherapy or chemotherapy pl
Nanoparticles are serving as contrast agents in different biomedical imaging modalities such as magnetic resonance imaging (MRI),computed tomography (CT),ultrasound tomography,positron emission tomogr
The first publication on intravenous immunoglobulin (IVIG) administration for children with immune thrombocytopenia ITP (Imbach et al.,The Lancet 1981; 1:1228-1231) evoked targeted immunomodulation in
Glomerulonephritis (GN) is an important cause of chronic kidney disease and renal failure.Current treatments consist of non-specific immunosuppressive medications which often associate with significan
Obesity and its co-morbidities such as diabetes,coronary heart disease and cancer are a fast growing health threat in today s society.Despite great efforts,pharmacotherapy of obesity has achieved litt
Insulin resistance is a central metabolic defect of type 2 diabetes.As our studies strongly indicate ectopic accumulation of lipids as a primary cause of insulin resistance,we investigated different a
Decline in skeletal muscle mass and function occurs in older men and women.Age-associated loss of muscle increases risk of functional limitations,falls,fractures,loss of independence and poor quality
The growth hormone secretagogue receptor (GHSR) is a GPCR whose natural ligand is the 28 amino acid peptide ghrelin.Ghrelin agonism of the GHSR in the CNS leads to growth hormone (GH) secretion and in
Using genome-wide association-and large-scale replication analyses we have convincingly mapped 30 loci (17 novel) that contribute to variation in lipoprotein concentrations and created a genetic risk