【摘 要】
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The Drosophila ovarian germline stern cells (GSCs) constantly experience self-renewal and differentiation,ensuring the female fertility throughout life.The
【机 构】
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上海交通大学Bio-X研究院/生命学院
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The Drosophila ovarian germline stern cells (GSCs) constantly experience self-renewal and differentiation,ensuring the female fertility throughout life.The balance between GSC self-renewal and differentiation is exquisitely regulated by the stem cell niche,the stem cells themselves and systemic factors.Increasing evidence has shown that the GSC regulation also involves epigenetic mechanisms including chromatin remodeling and histone modification.Here,we find that dBrel,an E3 ubiqnitin ligase,functions in controlling GSC self-renewal and germ cell differentiation via distinct mechanisms.Removal or knock down of dBre1 function in the germline or somatic niche cell lineage leads to a gradual GSC loss and disruption of H3K4 trimethylation in the Drosophila ovary.
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