【摘 要】
：
目的 观察肺康宁胶囊对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)模型大鼠的影响并探讨其机理.方法 将实验动物分为6组：正常对照组,模型对照组,肺康宁胶囊高、中、低剂量组,金水宝胶囊(阳性对照药)组.采用复合因素(熏香烟加气管注内毒素法)造成COPD大鼠模型,在第28天处死动物.观察肺康宁胶囊对模型大鼠体重、呼吸道分泌SIgA含量及肺功能
【机 构】
：
成都市成都市中西医结合医院呼吸内科 610041
【出 处】
：
中国医师协会中西医结合医师分会呼吸病专家委员会第二届学术研讨会
论文部分内容阅读
目的 观察肺康宁胶囊对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)模型大鼠的影响并探讨其机理.方法 将实验动物分为6组：正常对照组,模型对照组,肺康宁胶囊高、中、低剂量组,金水宝胶囊(阳性对照药)组.采用复合因素(熏香烟加气管注内毒素法)造成COPD大鼠模型,在第28天处死动物.观察肺康宁胶囊对模型大鼠体重、呼吸道分泌SIgA含量及肺功能的影响,并取大鼠肺和支气管等组织做病理检查.结果 肺康宁各剂量组较模型组大鼠体重有均有增加,各组与对照组比较,高、中剂量组有统计学意义(P＜0.05)；肺康宁胶囊高、中、低剂量组大鼠SIgA含量均较模型组高(P＜0.05,0.01),尤以高、中剂量组为显著(P＜0.01)；肺康宁高、中剂量组PEF、FEV0.3较模型组大鼠有均有增加(P＜0.05).结论 肺康宁胶囊可以明显改善COPD模型大鼠体重减轻、呼吸道分泌SIgA含量下降及改善气管多种病理改变,肺康宁高、中剂量组对模型大鼠存在的气流阻塞均有一定的改善作用,可能是肺康宁胶囊治疗COPD的机理之一.
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