【摘 要】
：
Circadian rhythms have been strongly implicated in mood disorders and other neuropsychiatric disorders.But the actual genes and related regulatory mechanisms remain to be found.In this study, we aim t
【机 构】
：
Department of Psychiatry,University of Illinois at Chicago,Chicago;State Key Laboratory of Medical G
【出 处】
：
2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议
论文部分内容阅读
Circadian rhythms have been strongly implicated in mood disorders and other neuropsychiatric disorders.But the actual genes and related regulatory mechanisms remain to be found.In this study, we aim to find out whether DNA methylation is involved in regulating circadian expressions, to prepare for discovering epigenetic biomarkers for related disorders.We performed the first genome-wide study of DNA circadian methylation in human blood, along with gene expression.
其他文献
目的：分析总结12例近视相关性内斜视的特征。方法：回顾性的选择2012年到2014年，在我院住院手术的中低度近视伴复视的内斜视病人12例(男7例，女5例)，术前均行头颅CT排除颅内疾患，并观察病情稳定六个月以上，手术方法均为内直肌退后加外直肌缩短。
目的：探讨CT在先天性泪囊突出诊断与治疗中的应用价值。方法：根据临床症状及体征考虑诊断为先天性泪囊突出患儿共26例(31只眼)，所有患儿进一步行CT检查进一步明确诊断。依据明确诊断后先天性泪囊突出患儿的CT检查结果，将需要进行手术治疗患儿是否存在下鼻道肿物分为两个治疗组。存在下鼻道肿物组在全麻下行先天性泪囊突出破囊手术。
目的：评价永存性原始玻璃体增殖症(Persistent hyperplastic primary vitreous,PHPV)的手术方法.方法：回顾分析2007年至2010年9例诊断PHPV手术治疗的病例,9例患儿均不是早产儿,无吸氧史,无其他异常,手术时年龄0.2-35个月.所有患儿均为表现为单眼白瞳症.前部型PHPV2例,后部型PHPV1例,混合型PHPV6例.
Clustered regularly interspaced short palindromic repeats (CRISPR) together with CRISPR-associated (Cas) proteins form the CRISPR-Cas system to defend against foreign nucleic acids of bacterial and ar
井冈霉素是主要的水稻纹枯病防治农用抗生素,其生物合成存在高产、稳定和高温调控等特点.为了阐明其高产机制,我们进行了井冈霉素野生型和工业高产菌株的精细基因组测定,发现了包括大片段缺失、InDel、SNV在内的多个突变.通过在野生型菌株中进行单一或系列缺失,我们发现3个大片段的缺失是工业菌株高产的主要原因.
Cyclin-dependent kinase, Cdkl, plays an important role in promoting DNA checkpoint activation and homologous recombination by regulating a number of DNA damage response enzymes.Cdk1 forms distinct com
As a complex disorder, PCOS (polycystic ovary syndrome) is present with heterogeneous characteristics originating from the combined effect of both environmental and genetic factors.On the genetic aspe
Fahr病是特发性脑基底节钙化(Idiopathic basal ganglia calcification,IBGC,OMIM213600)的俗称,是一种以大脑基底节或其他部位对称性钙化为特征的椎体外系遗传疾病.1850被首次报道,目前脑CT发现率为1-2％.基底节钙化常伴随偏头疼、癫痫发作、精神障碍、帕金森、脑梗和痴呆等锥体外系临床症状,使患者苦不堪言.Fahr病的致病基因是什么?2012年前
目的:探讨新型无,创产前检测技术在胎儿染色体非整倍体检测中的应用价值.方法:2011年4月19日至2013年12月31日在湖南省妇幼保健院接受孕妇外周血中胎儿游离DNA检测者共4004例,均为单胎,孕周(12～35+5)周,根据就诊原因分为唐氏综合征高危组、高龄组及其他原因组3组.提取孕妇外周血,进行血浆分离后提取胎儿游离DNA序列进行高通量测序分析,检测结果阳性者通过羊水穿刺或脐带血穿刺获取胎儿
Erythropoiesis is the process by which erythroid progenitors proliferate and differentiate into nonnucleated reticulocytes.Two distinct erythroid progenitors have been functionally defined in colony a