【摘 要】
：
目的 壬基酚(nonylphenol,NP)是环境内分泌干扰物的一种,因具有强大脂溶性而被广泛应用于工业、纺织业及生活用品中,目前对环境的污染甚为严重。众多研究证实NP长期积蓄于生物体内能对生殖系统、内分泌系统及心血管系统等产生不可忽视的毒性作用,而对其急性毒性作用的研究尚不明确。方法 本研究首先将10-7 M NP和10-5 M NP直接灌流离体心脏,观察10-7 M NP和10-5 M NP对
【机 构】
：
中国医科大学药学院药物毒理教研室,沈阳辽宁,110001;北海市人民医院药剂科,北海,广西壮族自治区,536000
【出 处】
：
第九届海峡两岸心血管科学研讨会暨首届台湾南部国际心脑血管科学研讨会
论文部分内容阅读
目的 壬基酚(nonylphenol,NP)是环境内分泌干扰物的一种,因具有强大脂溶性而被广泛应用于工业、纺织业及生活用品中,目前对环境的污染甚为严重。众多研究证实NP长期积蓄于生物体内能对生殖系统、内分泌系统及心血管系统等产生不可忽视的毒性作用,而对其急性毒性作用的研究尚不明确。方法 本研究首先将10-7 M NP和10-5 M NP直接灌流离体心脏,观察10-7 M NP和10-5 M NP对离体心脏心率(heart rate, HR)、冠脉流量(coronary flow,CF)、乳酸脱氢酶(lactate dehydrogenase,LDH)的影响；其次将10-7 M NP和10-5 M NP作用于离体心脏缺血再灌注模型中观察HR、CF、LDH、肌酸激酶(creatine kinase,CK)、梗死面积和超氧化物歧化酶(superoxide dismutase,SOD)等指标,探讨NP是否能够加重缺血再灌注损伤；最后将10-7 M NP和10-5 M NP分别与10-7 M 17β-雌二醇(17β-estradiol,E2)联合作用于缺血再灌注模型观察HR、CF、LDH、CK、梗死面积和SOD等指标,探讨NP是否能够干扰E2对缺血再灌注损伤心肌保护作用。
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