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Milk casein proteins can act as molecular chaperones: under conditions of stress, molecular chaperones stabilize proteins from unfolding, aggregating, and precipitating.In this work, the ability of casein proteins to protect whey protein from pressure-induced aggregation was examined.κ-casein depressed the pressure-induced aggregation of whey protein, and this function was dependent on the concentration of casein proteins and the pressure holding time.