【摘 要】
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Obesity increases the risk for type 2 diabetes through induction of insulin resistance.Treatment of type 2 diabetes has been limited by insufficient knowledge of insulin resistance.Although there have
【机 构】
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Pennington Biomedical Research Center,Louisiana State University,Baton Rouge,LA 78080,USA
【出 处】
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中华医学会第十二次全国内分泌学学术会议
论文部分内容阅读
Obesity increases the risk for type 2 diabetes through induction of insulin resistance.Treatment of type 2 diabetes has been limited by insufficient knowledge of insulin resistance.Although there havebeen several hypothesis for the pathogenesis of insulin resistance, none of them has led to development of effective drugs or therapies.Inflammation, mitochondrial dysfunction, hyperinsulinemia and lipotoxicity have received a lot of attention in the pathogenesis of insulin resistance.In addition, oxidative stress, ER stress, genetic background, aging, fatty liver, hypoxia and lipodystrophy are also used to explain the obesity-associated insulin resistance.
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