The Pearl River Delta region has good open base, where machinery industry market highlights the internationalization trend.Especially in Guangdong province, from equipment manufacturing industry big province turning to force to the equipment in the process of change, the enterprise of mechanical requests some talents with international view.Based on the CDIO idea, this paper proposed the establishment of the internationalization of the quality of professional English of mechanical talents training mode, and discussed the training objectives, requirements of talents and teaching methods A novel education mode was introduced, that is a multi subjects integrated (Multiple Subjects Integrated, MSI) CDIO mechanical specialty English teaching reform.