Activation of the canonical Notch-signaling pathway mediates ischemic brain injury in mice

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The canonical Notch-signaling pathway (CNSP) is characterized by Y-secretase-dependent release of Notch intracellular domain from cell membrane and subsequent translocation to the nucleus, where it activates a transcriptional program in coupled with the essential transcriptional factor RBP-J1.Ablation or attenuation of Notch receptor expression can remarkably impact stroke outcome in rodents2,3, suggesting that Notch signaling may be an important determinant for ischemic brain injury.
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