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  5. Biodegradable cross-linked N-(2-hydroxypropyl) methacrylamide copolymer micelles enhance cancer ther

Biodegradable cross-linked N-(2-hydroxypropyl) methacrylamide copolymer micelles enhance cancer ther

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：williamt
【摘 要】
：
Biodegradable cross-linked N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer micelles were proven to improve tumor accumulation by increase blood circulation time by our previous work;however,there
【作 者】
：
Zhou Zhou Yanxi Liu Yuan Huang 
【机 构】
：
Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年9期
【关键词】
：
HPMA copolymer pH responsive cross-linked micelles lysosomal escape nuclear targ 
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　　Biodegradable cross-linked N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer micelles were proven to improve tumor accumulation by increase blood circulation time by our previous work;however,there are intracellular physiological barriers after the micelles were intemalized, such as damages by lysosome and poor distributions of drug in nucleus.
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