【摘 要】
：
SMB (simulated moving bed) chromatography is a continuous separation process for binary fractionation.SMB,however,has a limitation in multi-components separation.SMB cascade (or tandem SMBs) [1],pseud
【机 构】
：
Dept.of Bio.Eng.,Inha Univ.,Incheon 402-751,Korea
【出 处】
：
第七届国际分离科学与技术会议(Proceedings of the 7th International Conferen
论文部分内容阅读
SMB (simulated moving bed) chromatography is a continuous separation process for binary fractionation.SMB,however,has a limitation in multi-components separation.SMB cascade (or tandem SMBs) [1],pseudo-SMB [2],SMB/chromatography hybrid system [3],and five-zones SMB [4] were introduced to overcome this limitation.As the SMB cascade is composed of two or more SMBs in one process,its installation cost and operation complexity are increased dramatically.Pseudo-SMB,SMB/chromatography hybrid system,and five-zones SMB are operated intermittently in the state of open-ring,causing high DC (desorbent consumption).The low DC is one of the most attractive advantages by SMB operation.In this study,seven-zones CC-SMB (center-cut simulated moving bed) process was introduced for separation of intermediate-retained component from ternary mixture.The seven-zones CC-SMB was developed by deletion of a zone from SMB cascade (composing two SMBs) and addition a by-pass stream.For the by-pass stream in the seven-zones CC-SMB,an enriching chamber was needed to obtain successful separation of intermediate-retained component.Triangle theory was applied to determine operating conditions of the seven-zones CC-SMB.Ternary mixture was composed of three amino acids-glycine,phenylalanie,and tryptophan.The seven-zone CC-SMB has two configurations of CC-SMB (R) and CC-SMB (E).CC-SMB (R) has the by-pass stream which is mainly composed of the least and intermediate-retained component.And,the by-pass stream of CC-SMB (E) mainly includes intermediate- and the most retained component.Two configurations of the seven-zones CC-SMB and the necessity of the enriching chamber in the by-pass stream were studied by using a commercial simulation program.One of the simulation results was validated experimentally by a home-made seven-zones CC-SMB equipment with 97% purity and 91% yield of intermediate-retained component.From the study of simulation and experiment,the seven-zones CC-SMB showed comparable results for the separation of intermediate-retained component.
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