【摘 要】
：
Glycosylation is a common tailoring reaction in natural product biosynthesis.In most cases, the sugar moiety is necessary for exerting their biological activiti
【机 构】
：
StateKeyLaboratoryofMicrobialResources,InstituteofMicrobiology,ChineseAcademyofSciences,Beijing10010
论文部分内容阅读
Glycosylation is a common tailoring reaction in natural product biosynthesis.In most cases, the sugar moiety is necessary for exerting their biological activities.Combinatorial biosynthesis is shown to be a powerful tool to engineer the glycosylation of natural products.A large number of new glycosylated products were generated, e.g., erythromycin, daunorubicin and mithramycin,and some of them showed enhanced bioactivity.These new glycosyl-diversified products offer new opportunities for drug development.
其他文献
雷纳霉素(leinamycin,LNM)在上世纪八十年代末由日本科学家从土壤中的链霉菌株Streptomyces atroolivaceus分离获得. 它由一个十八员环的大环内酰胺和一个含二硫键的五员环螺
在土壤样品中筛选到一株渗透压敏感的链霉菌.该菌产黑色素,在MS培养基上生长和产孢良好.在2CM和MM基本培养基上能够生长,但产孢较差.值得注意的是,该菌在R2YE培养基上不能生
黑莫他丁是一种具有环己酯肽二聚体结构的新型抗生素.在其生物合成途径中有三个细胞色素P450酶(HmtT,HmtN和HmtS),它们催化酯肽环上的后修饰反应.虽然这三种酶都以环己酯肽衍
环肽YM-216391分子中包含连续的恶唑/噻唑环,并且具有良好的抗肿瘤活性,前期研究中,我们确认了它是由核糖体方式合成,即先由核糖体产生一个前体肽,前体肽在一系列翻译后修饰
Rapamycin is a macrocyclic polyketide compound exhibiting immunosuppressive, anticancer,and antifungal activity.It is clinically important for treatment of orga
jadR*, encoding a TetR family transcriptional regulator, situated in the jadomycin biosynthetic gene cluster of Streptomyces venezuelae ISP5230.Disruption of ja
The cloning of large secondary metabolite biosynthetic gene clusters (20-210 kb) with high G+C content in actinomycetes is a significant challenge.In our work,
Little is understood about intrinsic regulatory mechanism of protein degradation of ECF sigma factors for bacterial cell development and environmental adaptatio
To construct a regulatory network, it is necessary to identify every transcription factors binding to a specific promoter.In this work, we developed a de nove d
友菌素(amicetin)是一类二糖核苷类抗生素,具有抗菌和抗病毒作用.友菌素的主要结构特点是以胞嘧啶为基本骨架,通过一位氮连接两个脱氧己糖amicetose和amosamine,形成罕见的α