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OBJECTIVES: To evaluate and explore the dynamic changes and clinical significance of serum P-selectin and bilirubin in elderly patients with Acute Cerebral Infarction (ACI).METHODS: Serum levels of P-selectin, bilirubin and high sensitivity C-reactive protein (hsCRP) were measured in deferent time and degree for 98 patients (mean age 69.5 ± 7.3 years) with cerebral infarction.Mild ACI group (n =38), moderate ACI group (n =35) and Severe ACI group (n =25) were selected according to their nerve function deficiency score, and thirty healthy subjects (mean age 68.2 ± 6.7 years) served as a control group.