【摘 要】
：
甲胎蛋白(alpha-fetoprotein,AFP)是原发性肝癌(HCC)临床诊断的重要生化指标,其激活表达与肝细胞的增殖分化状态密切相关.本课题组通过基因打靶研究发现,新型锌指蛋白ZBTB20是调控肝脏AFP基因表达的关键性转录抑制因子,ZBTB20基因敲除小鼠出生后肝脏AFP基因处于持续激活状态(PNAS,2008;105:10859).
【出 处】
：
第八届中国病理生理学会消化专业委员会学术会议
论文部分内容阅读
甲胎蛋白(alpha-fetoprotein,AFP)是原发性肝癌(HCC)临床诊断的重要生化指标,其激活表达与肝细胞的增殖分化状态密切相关.本课题组通过基因打靶研究发现,新型锌指蛋白ZBTB20是调控肝脏AFP基因表达的关键性转录抑制因子,ZBTB20基因敲除小鼠出生后肝脏AFP基因处于持续激活状态(PNAS,2008;105:10859).
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