【摘 要】
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Recombinant adeno-associate virus (rAAV) is a promising gene replacement vector.It has great advantages in its biological properties, which include integrat
【出 处】
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中国科协青年科学家论坛暨2006年第二届新生病毒性疾病控制学术研讨会
论文部分内容阅读
Recombinant adeno-associate virus (rAAV) is a promising gene replacement vector.It has great advantages in its biological properties, which include integration into human chromosomes, nonpathogenicity, transduction of quiescent cells, long-term expression of transgene, no immune response after gene transfer, no toxicity after vector delivery and a wide range of hosts.In contrast to other viral vectors, rAAV is capable of efficiently bypassing the myofiber basal lamina and transducing mature muscle cells.Thus far, AAV vector has demonstrated the best gene transfer efficiency and longevity among all viral and non-viral vectors tested in muscle tissue.
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