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Bone tissue engineering,aiming at developing bone substitutes for repair and regeneration of bone defects instead of using autologous bone grafts,is one of the fastest-growing branches in the field of tissue engineering.Induced pluripotent stem cell-derived mesenchymal stem cells (iPSC-MSCs) are a new type of MSCs which have the potential to differentiate into any cells of mesoderm cells including osteoblasts.