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Mechanotransduction has an important role in physiology.Biological processes including sensing touch and sound waves require as-yet-unidentified cation channels that detect pressure.Mouse Piezo1 (MmPiezo1) and MmPiezo2 (also called Fam38a and Fam38b, respectively) induce mechanically activated cationic currents in cells;however, it is unknown whether Piezo proteins are pore-forming ion channels or modulate ion channels.