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  5. pH-Sensitive mixed micelles for overcoming drug-resistance and enhancing antitumor efficacy

pH-Sensitive mixed micelles for overcoming drug-resistance and enhancing antitumor efficacy

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：ycmk07js2
【摘 要】
：
Doxorubicin (DOX) is a widely used chemotherapeutic drug for the treatment of several types of cancers.However,its side effects and the development of multidrug resistance (MDR) greatly reduced the an
【作 者】
：
Dandan Sun Xueming Lv Yongjian Wang 
【机 构】
：
Key Laboratory of Bioactive Materials,Ministry of Education,College of Life Sciences,Nankai Universi
【出 处】
：
Fourth Symposium on Innovative Polymers for Controlled Deliv
【发表日期】
：
2016年11期
【关键词】
：
multidrug resistance P-glycoprotein TPGS DOX 
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　　Doxorubicin (DOX) is a widely used chemotherapeutic drug for the treatment of several types of cancers.However,its side effects and the development of multidrug resistance (MDR) greatly reduced the antitumor efficacy.There are many mechanisms responsible for MDR and the overexpression of P-glycoprotein (P-gp) plays a major role in mediating MDR.
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