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目的:通过观察肠安I号对大鼠结肠黏膜NF-κB影响,探讨促炎因子NF-κB的活化在IBS发病机制中的作用。方法:用免疫组化方法检测大鼠结肠黏膜NF-κB含量。结果:肠安I号各剂量组IOD降低与模型组比较有统计学意义(P<0.05)。结论:肠安I号各剂量组对D-IBS作用机制可能与抑制NF-κB的活化有关。
OBJECTIVE: To observe the effect of Chang’an No. I on NF-κB in rat colonic mucosa, and to explore the role of activation of proinflammatory cytokines NF-κB in the pathogenesis of IBS. Methods: The content of NF-κB in rat colonic mucosa was detected by immunohistochemistry. Results: Compared with the model group, the decrease of IOD in each dose of Chang’an I was statistically significant (P<0.05). Conclusion: The mechanism of D-IBS may be related to the inhibition of NF-κB activation in each dose of Chang’an I.