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5. The effect of PICK1 PDZ domain inhibitor FSC231 on long-term potentiation of hippocampus in rat

The effect of PICK1 PDZ domain inhibitor FSC231 on long-term potentiation of hippocampus in rat

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：llpgxyu

【摘 要】

：

Aim: FSC231 is the specifical PDZ domain inhibitor of PICK1 which has been suggested as a potential drug target against brain ischemia, pain and cocaine addiction.Our previous study has shown that FSC

【作 者】

：

Fei CAI Cai-rong LI Jiang-hua WANG Xin YUAN Wei YU Wei SONG Zhi-Peng ZHANG 

【机 构】

：

Department of Pharmacology, Hubei University of Science and Technology, Xianning 437100, China; Hube

【出 处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

FSC231 PICK1 long-term potentiation hippocampus 

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Aim: FSC231 is the specifical PDZ domain inhibitor of PICK1 which has been suggested as a potential drug target against brain ischemia, pain and cocaine addiction.Our previous study has shown that FSC231 reversed cocaine-induced conditioned place preference, but its exact mechanism is still unknown.

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