【摘 要】
:
Aim: The role of histone deacetylases (HDACs) and the potential of these enzymes as therapeutic targets for cancer is an area of rapidly expanding investigation.In addition to histones, HDACs have man
【机 构】
:
Pharmacological Institute, College of Medicine, National Taiwan University, Taiwan, China
【出 处】
:
The 12th Meeting of the Asia Pacific Federation of Pharmacol
论文部分内容阅读
Aim: The role of histone deacetylases (HDACs) and the potential of these enzymes as therapeutic targets for cancer is an area of rapidly expanding investigation.In addition to histones, HDACs have many nonhistone protein substrates which have a role in regulation of gene expression, cell proliferation, cell migration, cell death,and angiogenesis.In this study, the anti-angiogenic effects of a novel synthetic HDAC inhibitor, MPT0G013, in HUVECs were investigated.
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