【摘 要】
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Background: Breast carcinoma is the commonest cancer among Singaporean women.Syndecan-1 is a transmembrane heparan sulphate proteoglycan.Previous studies have shown that heparan sulphate is overexpres
【机 构】
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Department of Surgery National University of Health Sciences (NUHS) Singapore
【出 处】
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(BITs 3rd Annual World Cancer Congress-2010, Breast Cancer C
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Background: Breast carcinoma is the commonest cancer among Singaporean women.Syndecan-1 is a transmembrane heparan sulphate proteoglycan.Previous studies have shown that heparan sulphate is overexpressed in breast carcinoma,regulating cancer proliferation and invasion.Overexpression of Syndecan-1 is associated with aggressive breast cancer in Caucasian populations.However, the expression pattern of syndecan-1 in breast cancer in Asian women is unknown.Aim: To determine if Syndecan-1 can be used as biomarker and prognostic factor for breast carcinoma in Asian women.Methods/materials: Breast tissue microarrays were constructed from archival specimens of low, moderate and high grade breast cancer and non-cancerous breast tissues from Asian women obtained from the Department of Pathology.lmmunnohistochemical staining was carried out using specific antibodies against Syndecan-1 by the labeled streptavidin biotin method.Clinicopathological parameters such as tumour size, histological type and grade, lymph node status were retrieved from computerised records.Results: 198 breast cancer microarrays and 61 normal breast tissue microarrays were obtained between 2005-2007.The mean age was 53.6 years old (range 28-90).The majority (84.3%)was Chinese.Preliminary finding shows that there is a statistically significant syndecan-1 staining of tumour tissues compared to normal breast tissue, hence suggesting a possible role of syndecan-1 as a biomarker in breast cancer in Asian women.Conclusion: Syndecan-1 may have a role as a biomarker for breast carcinoma in Asian women.
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