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  5. Reversible RNA adenosine methylation in biological regulation--dissecting the pathogenic mechanism o

Reversible RNA adenosine methylation in biological regulation--dissecting the pathogenic mechanism o

来源 :2015 Genomics Frontiers Symposium(2015基因组学前沿研讨会) | 被引量 : 0次 | 上传用户：marrymattion
【摘 要】
：
N6-methyladenosine (m6A) is the most abundant internal modification in the mRNA of all higher eukaryotes.This modification has been shown to be reversible in mammals;it is installed by a methyltransfe
【作 者】
：
贾桂芳 
【出 处】
：
2015 Genomics Frontiers Symposium(2015基因组学前沿研讨会)
【发表日期】
：
2015年3期
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N6-methyladenosine (m6A) is the most abundant internal modification in the mRNA of all higher eukaryotes.This modification has been shown to be reversible in mammals;it is installed by a methyltransferase heterodimer complex of METTL3 and METTL14 in aid of WTAP, and can be erased by demethylases FTO and ALKBH5;both are iron(II)-and α-ketoglutarate-dependent dioxygenases.This modification exhibits significant functional roles in various biological processes.
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