【摘 要】
：
Coenzyme Q 10 (CoQ 10),a lipophilic nutritional supplement,has increased in popularity in many countries because of growing evidence of therapeutic benefits and an excellent safety profile.Improved ce
【机 构】
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Cincinnati Children's Hospital Medical Center USA
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Coenzyme Q 10 (CoQ 10),a lipophilic nutritional supplement,has increased in popularity in many countries because of growing evidence of therapeutic benefits and an excellent safety profile.Improved cellular penetration and delivery of drugs into mitochondria represents a significant challenge,but may be particularly important for diseases associated with increased free radical production,oxidative/nitrosative stress,and disorders of energy metabolism.Currently most CoQ10 formulations contain ubiquinone-10 (the oxidized form of CoQ 10).However,an important drawback of ubiquinone-10 is its limited bioavailability.Administration of the reduced form of CoQ 10 (ubiquinol-10) may improve absorption,tissue uptake,and more immediate beneficial effects.
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