【摘 要】
：
进化上高度保守的Wnt/Wingless信号通路在动物的器官发育、能量代谢和干细胞维持等过程中发挥重要作用,并与多种疾病的发生有密切联系.然而迄今为止,人们对于该通路的信
【机 构】
：
InstituteforNutritionalSciences,ShanghaiInstitutesforBiologicalSciences,CAS,Shanghai,200031,China
论文部分内容阅读
进化上高度保守的Wnt/Wingless信号通路在动物的器官发育、能量代谢和干细胞维持等过程中发挥重要作用,并与多种疾病的发生有密切联系.然而迄今为止,人们对于该通路的信号转导机制还缺少充分的认识.通过转基因果蝇株的过表达筛选,我们发现了Wnt信号通路中一个新调控因子,蛋白激酶Nek2,促进Wnt信号的传递.Nek2与Wnt信号通路的重要调控因子Dsh相互作用,通过Dsh影响信号传递.进一步的研究显示,Nek2通过对Dsh N-端的磷酸化增强Dsh活性,激活Wnt信号通路.同时Nek2通过对Dsh C-端的磷酸化降低Dsh蛋白的稳定性,防止信号通路过度激活.最后,我们发现Nek2与另一个蛋白激酶CK1ε具有功能冗余性,同时抑制这两个蛋白会阻断Wnt信号的传递和影响果蝇器官发育.
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