【摘 要】
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CIC-7 is one of important members of voltage-gated chloride channel family (CIC channels).It is a kind of chloride channel of late endosomes and lysosomes.I
【机 构】
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DepartmentofOralBiology,SchoolofStomatology,TheFourthMilitaryMedicalUniversity.145WestChangleRoad,Xi
【出 处】
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Wnt信号、器官发育和干细胞国际学术大会(Wnt Signaling,Organogenesis,and Stem Ce
论文部分内容阅读
CIC-7 is one of important members of voltage-gated chloride channel family (CIC channels).It is a kind of chloride channel of late endosomes and lysosomes.In osteoclasts, it may cooperate with H+-ATPases in acidifying the resorption lacuna.In mice and man, loss of CIC-7 causes osteopetrosis, a disease characterized by defective bone resorption.Some of osteopetrosis patients shows dental defects, such as some missing teeth, failure of teeth to erupt or delayed permanent tooth eruption.Clcn7-/-(KO) mice are smaller, have dysmorphic heads, an abnormal body posture, and short limbs.An interesting finding in CIC-7 knockout mice is that the teeth were formed, but did not erupt.
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