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目的了解慢性阻塞性肺疾病急性发作期(AECOPD)患者血尿酸肌酐比与肺弥散功能的相关性。方法选取我科2012年3月至2014年3月因AECOPD住院患者共302名进行回顾性分析,排除痛风、肾功能不全和明显肺部感染者,收集患者临床资料、动脉血气分析、肾功能、肺通气功能及弥散功能指标,并进行相关性分析。结果患者血尿酸肌酐比与DLCO、氧合指数、FEV1实/预%、FVC实/预%存在负相关,相关系数分别为-0.62,-0.57,-0.32,-0.38,P值均<0.05,其中与DLCO、氧合指数相关性最为明显,提示肺交换功能越差、缺氧程度越重,血尿酸肌酐比升高越明显。结论血尿酸肌酐比与DLCO有较高的关联性,当AECOPD患者无法行肺弥散功能检测时,血尿酸肌酐比可作为一较好的评估肺弥散功能的参考指标。
Objective To investigate the relationship between serum uric acid creatinine ratio and pulmonary diffuse function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 302 hospitalized patients with AECOPD were selected from March 2012 to March 2014 in our department for retrospective analysis. Gout, renal insufficiency and pulmonary infection were excluded. The clinical data, arterial blood gas analysis, renal function, Pulmonary ventilation and diffuse function index, and correlation analysis. Results The serum uric acid creatinine ratio was negatively correlated with DLCO, oxygenation index, FEV1 real / pre%, FVC real / pre%, the correlation coefficients were -0.62, -0.57, -0.32, -0.38, P < Among them, the correlation with DLCO and oxygenation index was the most obvious, suggesting that the worse the lung exchange function, the more severe the hypoxia, the more obvious the ratio of serum creatinine increased. Conclusion Serum uric acid creatinine ratio has a higher correlation with DLCO. When AECOPD patients can not detect pulmonary diffuse function, serum uric acid creatinine ratio can be used as a good reference index to evaluate pulmonary diffusing function.