Pancreatic cancer (PANC) is the 4th leading cause of cancer death among men and women in the United States.PANC is often dubbed the silent killer because it seldom causes symptoms until advanced.As a result, the morbidity rate equals the mortality.It is now clear that the effective control of this deadly disease is by prevention.The role of diet and nutrition in the prevention of PANC has not been adequately studied.Diets contain a diverse array of active components that have variety types of biological activities, and the potent cancer prevention activity may be due to the interaction between active components in a synergistic or an additive manner.The objective of this research was to identify the synergistic combination regimen of dietary active components for PANC prevention.We applied cell-based bioassays to compare the relative potencies of a panel of dietary components that are commonly present in fruits and vegetables to identify the potent components for growth inhibition of PANC cell lines in vitro.We further determined the combined effects of candidate components to identify potential synergistic combinations.