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  5. Fasudil, a Rho kinase inhibitor, selectively enhances activation of Kv7.4 K+ channels

Fasudil, a Rho kinase inhibitor, selectively enhances activation of Kv7.4 K+ channels

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：xtt1027
【摘 要】
：
Fasudil is a selective and potent RhoA/Rho kinase (ROCK) inhibitor and vasodilator.Since it was discovered, it has been used for the treatment of cerebral vasospasm, as well as to improve the cognitiv
【作 者】
：
Xuan Zhang Yuan-yuan Zhang Li Chu Hai-lin Zhang 
【机 构】
：
Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
【发表日期】
：
2013年2期
【关键词】
：
Fasudil Kv7 K+channel retigabine HEK293 cell DRG 
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Fasudil is a selective and potent RhoA/Rho kinase (ROCK) inhibitor and vasodilator.Since it was discovered, it has been used for the treatment of cerebral vasospasm, as well as to improve the cognitive decline seen in stroke victims.And it has been found to be effective for the treatment of pulmonary hypertension, and enhance memory and improve the prognosis of Alzheimers patients.In this study, we characterized the effects of Fasudil on Kv+ channels and compared its effects with the well-established Kv7 opener retigabine.A perforated whole-cell patch technique was used to record Kv7 currents expressed in HEK293 cells and M-type currents from rat DRG neurons.
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