【摘 要】
：
Small molecule systemic chemotherapy has been relatively ineffective in the treatment of malignant solid tumors.This is primarily due to sub-therapeutic drug accumulation within individual brain tumor
【机 构】
：
National Institute of Biomedical Imaging and Bioengineering National Institutes of Health USA
【出 处】
：
中国上海第七届国际新药发明科技年会
论文部分内容阅读
Small molecule systemic chemotherapy has been relatively ineffective in the treatment of malignant solid tumors.This is primarily due to sub-therapeutic drug accumulation within individual brain tumor cells following drug extravasation across the porous blood-brain tumor barrier of malignant solid tumor microvasculature.Nanoparticles of sizes ranging between 7 nm and 10 nm in diameter can be used to deliver therapeutically effective concentrations of small molecule chemotherapy drugs across the blood-tumor barrier into individual tumor cells,since these particles are sufficiently smaller than the 12 nm physiologic upper limit of pore size within the blood-tumor barrier,and maintain peak steady-state blood concentrations for several hours.We have validated the initial therapeutic efficacy of a prototypical imageable nanoparticle bearing chemotherapy,the Gd-G5-doxorubicin dendrimer,in the orthotopic RG-2 rodent malignant glioma model.Here I will present this novel strategy,and discuss the therapeutic implications thereof,in the context of a review of the historical strategies.
其他文献
Rabies is still a serious public health problem in the developing countries.It is believed that at least 60,000 human deaths occur each year,and more than 10 million people are reported to receive pos
Tadalafil is a phosphodiesterase-5 inhibitor.It has the disadvantage of poor aqueous solubility.Therefore,it is important to develop an effective method to enhance the solubility of the drug.The aim o
Nanoparticles possess enormous potential as diagnostic imaging agents and hold promise for the development of multimodality agents with both imaging and therapeutic capabilities.Yet,some of the most p
Over the past decade,routine chemistry outsourcing to Asia has given way to full scale drug discovery partnering due in large part to the resettlement of highly skilled,Western trained scientists and
The partnership between Pierre Fabre,a multinational pharmaceutical and cosmetics company,and Pharmaron,a premier drug R&D CRO,has been highly productive and beneficial for both companies.Initially,Pi
As results of restructure and consolidation of global pharma industry,drug discovery outsourcing trends to India and China has been significantly increased in past years and will continue to increase.
Statins-inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase-are known to reduce blood cholesterol levels.Statin therapy is regarded as well tolerated,however serious adverse ef
A series of tetrahydro-1H-indol-2-ylmethyleneindolin-2-ones were synthesized and their inhibition toward Aurora A & B kinases was investigated.Their preparation was initiated by reaction of cyclohexan
The gene sequences of the hemagglutinin (HA) subtype H1 of the several strands of influence virus are analyzed.The samples of the 1918 strand are inscribed in that family of influenza virus adapted to
Introduction:Therapeutic treatments of septic forms of equine osteoarthritis (S-OA) are difficult because of pure understanding disease induction (Ross and Dyson,2003).That is why the study of S-OA is