ERK-Pathway Inhibitor and Proliferative Eye Disease

来源 :2005 WHTS3rd Annual Congress of International Drug Discovery | 被引量 : 0次 | 上传用户：zhuzhenxing1

【摘要】

：

P.C.Kothary, A.Britton, N.Lewis, V.Patel, D.Rivers, and M.A.Del Monte, Department of Ophthalmology, University of Michigan Medical Center, Ann Arbor, MI Introduction: Insulin, the most common therapy

【作者】

：

Piyush C.Kothary

【机构】

：

Sr.Res.Associate, University of Michigan, USA

【出处】

：

2005 WHTS3rd Annual Congress of International Drug Discovery

【发表日期】

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2005年12期

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　　P.C.Kothary, A.Britton, N.Lewis, V.Patel, D.Rivers, and M.A.Del Monte, Department of Ophthalmology, University of Michigan Medical Center, Ann Arbor, MI Introduction: Insulin, the most common therapy for type I diabetes mellitus, has been shown to induce proliferation of hRPE cells.Extra cellular signal-regulated protein kinase 2 (ERK2) has been shown to mediate insulin action.Since abnormal cellular proliferation has been implicated in the ocular complications of patients with diabetes and abnormal human retinal pigment epithelial cell (hRPE) proliferation and metaplasia has been implicated in diabetic retinal detachment, we investigated the effect of insulin on ERK2 and phosphorylated ERK1-2 (pERK1-2) synthesis in hRPE cells.

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ERK-Pathway Inhibitor and Proliferative Eye Disease

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