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The glial cell line-derived neurotrophic factor (GDNF) with its powerful protective effects on midbrain dopamine (DA) neurons provides a promising future for Parkinsons disease treatment.GDNF exerts biologic effect via a multicomponent receptor system including the ligand binding receptor-GDNF family receptor-alphal (GFRα1) and the signaling receptor-RET.In RET-negative cells,one type of neural cell adhesion molecules (NCAM) has been identified as an alternative signaling receptor.However,studies centered around whether NCAM as one kind of GDNFs signaling receptors mediates its protective effect on DA neurons are not reported.The purpose of our present study was to investigate whether NCAM could mediate the events of GDNF on midbrain DA neurons and its role in the protective effect of GDNF on mature and immature DA neurons lesion-induced by 6-OHDA.