【摘 要】
：
Recently,the self-assembly of functionalized small molecular photosensitizes(PSs)into “one-for-all” nanoparticles has drawn great attention in phototheranostic cancer treatment because of their high t
【机 构】
：
College of Chemistry,Fuzhou University,Fuzhou 350108,China
论文部分内容阅读
Recently,the self-assembly of functionalized small molecular photosensitizes(PSs)into “one-for-all” nanoparticles has drawn great attention in phototheranostic cancer treatment because of their high tumor specificity,switchable photoactivity,multifunctional design,and relatively simple component(s).[1] The regulation of self-assembled nanoparticles of different sizes is highly interesting,but it is still very rare thus far.Thus,we have develop herein a novel strategy for size-tunable self-assembled nanophotosensitizers with targeting-triggered photoactivities based on an amphiphilic phthalocyanine-biotin conjugate.The particle sizes of the nanophotosensitizers could be changed from 10 nm to 90 nm through the regulation of the amount of Cremophor EL.[2]
其他文献
As a well-known toxic air pollutant,SO2 displays broad and complex toxicological effects,including oxidative damage,deoxyribonucleic acid(DNA)damage,changes in ion channels and signal transduction as
The development of near-infrared(NIR)fluorescent probe(650-900 nm)has gained increasing attention over the last few decades because of their potential applications in several important fields such as
Effective delivery of probes and drugs to tumor cells remains major challenge for cancer diagnosis and treatment.Nanoparticles capable of escaping the reticuloendothelial system while improving endocy
While most nanomedicine is playing important role in cancer therapy,the nanomaterial may pose a threat to the integrity of the vasculature system.It has been earlier reported that certain nanoparticle
In recent study,SWNHs has a high near-infrared optical absorption capacity,which can effectively convert near-infrared light into heat[1].However,its poor water dispersion and adsorption of plasma pro
碳量子点(CDs)具有荧光发射优异、毒性低和生物相容性良好等优点，但CDs 发射波长短、特异性靶向能力缺乏等不足限制了其在生物成像、治疗等生物领域的实际应用。在此，我们以对氨基偶氮苯为原料一步水热合成了一种具有红色荧光发射的CDs(RCDs)。体外细胞实验表明RCDs 具有较小的细胞毒性，适用于生物研究。共聚焦成像研究进一步揭示RCDs通过与细胞核内RNA 作用有效地靶向到核仁，实现对细胞核的成像
单壁碳纳米角(Single-wall carbon nanohorns,SWNHs)在合成过程中不需使用金属催化剂催化,使其表现出低毒性；同时,其能有效地将近红外光转换成热,是一种理想的纳米光热试剂[1]。然而,水溶性差、靶向性缺乏的不足严重限制了它在生物医学上的实际应用。二氢卟吩e6(Chlorine e6,Ce6)具有高的单线态氧量子产率,可以被用于光动力治疗肿瘤,但其在血液中易被清除的不足限
Although considerable clinical attempts on various types of cancers have achieved,photodynamic therapy(PDT)still suffers attenuated therapeutic effects due to the developed resistance of cancer cells.
光热和光动联合治疗(SPT),在理论上可以表现出“1+1 > 2”的协同效应。[1]然而,由于肿瘤内的微环境缺氧,光动力治疗的效果会受到严重限制,导致光热治疗在协同治疗过程中起主要治疗作用。进而导致传统光动力和光热治疗的联合不能充分发挥协同治疗的效果。因此,需要开发新的联合治疗药物以实现光动力和光热联合治疗的真正协同作用。我们设计合成了一种多功能聚合物PPAIB,并基于MnO2 纳米片构筑了联合光